Most cancers remain incurable. Over the last 60 years, even with the development and advances in chemo-, radio-, immuno-, hormone-directed therapy, and small biologics  we still have not reached our treatment goals.  A more serious problem is the impact these treatments have on the cancers themselves and their side effects.   It is now scientifically proven that these therapies select for the development of more aggressive and drug-resistant tumors. A good example is the treatment of HER2-positive breast cancer, which often results in ~25% of patients developing resistance and relapsing from Trastuzumab treatment.   Physical-directed therapies, such as heat, cold, or radiation, are immune to mutational alterations and avoid genetic selection pressures.